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Architects of structural biology : Bragg, Perutz, Kendrew, Hodgkin
Thomas, J. M.
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| 자료유형 | E-BOOK |
|---|---|
| 서명/저자사항 | Architects of structural biology : Bragg, Perutz, Kendrew, Hodgkin/ John Meurig Thomas. |
| 개인저자 | Thomas, J. M.(John Meurig), author. |
| 판사항 | First edition. |
| 발행사항 | Oxford, United Kingdom ; New York, NY: Oxford University Press, 2020. |
| 형태사항 | 1 online resource. |
| 기타형태 저록 | Original 0198854501 9780198854500 |
| ISBN | 9780192596710 0192596713 9780191888793 0191888796 |
| 일반주기 |
Includes index.
|
| 요약 | Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of the twentieth century. They exploited a discovery made over a century ago about the nature of X-rays, and thereby created a new branch of science. This enabled them to elucidate, in atomic detail, the structure and mode of action of molecules of the living world: enzymes, vitamins, and viruses, as well as antibiotics. Perutz and Kendrew, from their pioneering work using X-ray diffraction on haemoglobin and myoglobin, the proteins that transport and store oxygen in all animals, led them to establish in 1962 one of the most successful research centres ever - the Laboratory of Molecular Biology (LMB) in Cambridge. Medicines discovered there are used worldwide to treat leukaemia, arthritis, and other diseases. Their work also led to the creation in the United States of the Protein Data Bank that guides scientists in understanding the misfolding of proteins, which cause Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. This book is first a memoir of these scientists and their contemporaries, many of them friends of the author. Second, it is an insight into the great excitement associated with structural molecular biology, which directly informs our understanding of ourselves. Third, it describes how two renowned research centres in the United Kingdom - the LMB and the Davy-Faraday Research Laboratory - achieved iconic status. It also highlights the importance of the popularization of science, of which Bragg, Perutz, and Kendrew, as well as Dorothy Hodgkin (who solved the structures of penicillin and vitamin B12) were experts. |
| 주제명(개인명) | Bragg, William Henry,1862-1942. Perutz, Max F. Kendrew, John C.(John Cowdery), -- 1917-1997. Hodgkin, Dorothy,1910-1994. Bragg, William Henry,1862-1942. -- fast -- Hodgkin, Dorothy,1910-1994. -- fast -- Kendrew, John C.(John Cowdery), -- 1917-1997. -- fast -- Perutz, Max F.fast -- |
| 주제명(단체명) | Laboratory of Molecular Biology --History. |
| 주제명(지명) | Great Britain. --fast |
| 일반주제명 | Scientists --Great Britain --History --20th century. Molecular biology --History --20th century. Proteins --Structure --Research --History --20th century. Molecular biology. Scientists. |
| 언어 | 영어 |
| 바로가기 | URL |
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